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・ FOC
・ FOC (album)
・ FOC Farsta
・ Foca
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・ Foca Cove
・ Foca Point
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・ Focaal
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・ Focal adhesion
Focal adhesion targeting region
・ Focal and diffuse brain injury
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・ Focal dermal hypoplasia
・ Focal dystonia
・ Focal facial dermal dysplasia
・ Focal fatty liver
・ Focal hyperhidrosis
・ Focal infection theory
・ FOCAL International
・ Focal length
・ Focal mechanism
・ Focal neurologic signs


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Focal adhesion targeting region : ウィキペディア英語版
Focal adhesion targeting region

In molecular biology, the focal adhesion targeting region is a conserved domain found on focal adhesion kinases.
Focal adhesion kinases (FAK) are tyrosine kinases found in focal adhesions, intracellular signalling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal focal adhesion targeting (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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